Lymecycline 408mg capsules and Differin gel

Lymecycline 408mg capsules and Differin gel work together to help clear spots, blackheads and whiteheads caused by acne.

A box of 28 Lymecycline 408mg capsules alongside a box containing 45g of Differen 0.1% gel
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Prices from £65.00

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Lymecycline 408mg capsules and Differin gel 0.1 % w/w


What are lymecycline 408mg capsules and Differin gel and what are they used for?

Lymecycline 408mg capsules contain an antibiotic which effectively kills bacteria that causes acne. Bacteria and dead skin cells can get trapped in your pores and cause spots. Acne can come up as blackheads, whiteheads and pustules on your face, back or chest.

Differin gel is a retinoid. Retinoids work by helping the turnover of dead skin cells on the surface of the skin, which means they don’t block your pores. It also helps reduce inflammation, redness and soreness caused by acne.

You cannot buy lymecycline 408mg capsules and Differin gel over the counter at a pharmacy, but they are available from Asda Online Doctor as a combination treatment for acne.

How to use lymecycline 408mg capsules and Differin gel

You should take 1 lymecycline 408mg capsule a day, ideally in the morning. Always swallow your lymecycline 408mg capsule whole with a glass of water.

Some medicines may interact with lymecycline and affect how well it works. The following medicines should be taken 2 hours before, or 2 hours after taking your Lymecycline 408mg capsules:

  • antacids and proton pump inhibitors (for indigestion and ulcers), such as omeprazole or lansoprazole
  • quinapril (for high blood pressure)
  • medicine or supplements that contain calcium, aluminium, magnesium, zinc or iron

Each pack of lymecycline 408mg capsules contains 84 capsules and is enough for a 12 week course.

You should apply Differin gel at night before going to bed. Make sure to thoroughly wash and dry the area to be treated before applying Differin gel. Then spread a thin layer of Differin gel onto the affected areas using your fingertips and rub in gently, avoiding your eye area.

It may take up to 6-8 weeks to see an improvement with this combination treatment.

Who can use lymecycline 408mg capsules and Differin gel?

You should not take lymecycline 408mg capsules or use Differin gel if you are:

  • allergic to lymecycline or any other tetracycline antibiotics, such as doxycycline, oxytetracycline or minocycline
  • have an allergy to adapalene or any of the ingredients listed in Differin gel
  • allergic to any of the other ingredients listed in lymecycline 408mg capsules
  • receiving treatment for kidney disease
  • pregnant, planning to become pregnant or breastfeeding

Check with your doctor before taking lymecycline 408mg capsules if you have:

  • liver or kidney disease
  • been diagnosed with myasthenia gravis
  • systemic lupus erythematosus

Avoid using Differin gel if you:

  • have open cuts or eczema
  • find your skin is sensitive or irritated after application
  • use corticosteroids on your skin
  • are going to be spending time in direct sunlight or under artificial UV light including sunbeds

Before you use lymecycline 408mg capsules or use Differin gel, you should tell your doctor if you take:

  • tablets or capsules that contain retinoids, like isotretinoin
  • high doses of vitamin A
  • blood thinners, such as warfarin, aspirin or rivaroxaban
  • diuretics, such as furosemide
  • barbiturates or medicines for epilepsy, such as phenobarbitone, phenytoin or carbamazepine
  • the anaesthetic Methoxyflurane
  • lithium

Women who are using this treatment should make sure they are using effective contraception if they are sexually active. Long acting reversible contraception such as the implant or coil are recommended. If using a contraceptive pill, condoms should also be used. This is because of risks to a baby if you become pregnant when using this.

For more details, check the Differin gel patient information leaflet or lymecycline 408mg capsules patient information leaflet.

There are other treatment options for acne available from Asda Online Doctor such as:

  • Zineryt (which contains the antibiotic erythromycin)
  • Epiduo (adapalene and benzoyl peroxide)
  • Aknemycin Plus (tretinoin and erythromycin)
Medically reviewed by:
Dr Kathryn Basford

Dr Kathryn Basford is a qualified GP who works as a GP in London, as well as with ZAVA. She graduated from the University of Manchester and completed her GP training through Whipps Cross Hospital in London.

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Article created: 14 Oct 2021

Last reviewed: 14 Oct 2021

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Asda Online Doctor by ZAVA offers a range of options to manage acne symptoms, including antibiotics, anti-inflammatories for inflamed skin, and combination treatments that include Zinc to help skin repair.

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