How to inject Wegovy
Medically reviewed by
Dr Kathryn BasfordLast reviewed: 02 Jun 2026
At the start of your treatment with Wegovy, you’ll follow a dosing schedule to reach the maintenance dose. This can reduce very common side effects. Each Wegovy pen contains 4 doses, which will last 4 weeks. You’ll increase your dose when each pen finishes. Wegovy should be taken alongside a diet and exercise plan for the best weight loss results.
Understanding how to take Wegovy will help you get the most out of your prescription. Below, we look at how to take Wegovy for weight loss, how to use the Wegovy pen, and how to inject Wegovy.
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Everything you need to know about the Wegovy pen
Wegovy (semaglutide) is used to aid weight loss and is injected once a week. Each pen comes with 4 doses pre-prepared and is easy to use for people with no experience with injections. This makes it easier for people who are worried about administering the correct dose or don’t know how to draw up medication and then inject it. All you need to do is check the dose and press it against your skin to administer it (more on this below).
Each Wegovy pen contains 4 doses, which means it’ll last for 4 weeks as long as you’re taking 1 injection per week. You’ll slowly increase your dose every 4 weeks until you reach 7.2mg (the maintenance or maximum dose of Wegovy). The only exception to this is the 7.2mg dose, which is available as a pre-filled single dose pen. This means that each pen contains your 7.2mg dose, once you have injected it you must discard it. For a 4 weeks supply of 7.2mg you will receive 4 single-use pens.
Taking Wegovy at the same time and day every week, and following the correct dosing schedule, will improve how effective it is. Always take Wegovy exactly as prescribed. If you struggle with using your pen or get side effects that bother you or that aren’t going away, speak to your doctor.
The Wegovy course
The Wegovy course is the best way to reach the maintenance dose with as few side effects as possible. Taking Wegovy this way can:
- get your body used to the medication
- decrease very common side effects, like nausea (feeling sick) and vomiting (being sick)
The Wegovy course is the best way to reach the maintenance dose with as few side effects as possible. Taking Wegovy this way can:
- get your body used to the medication
- decrease very common side effects, like nausea (feeling sick) and vomiting (being sick)
How many doses are in a Wegovy pen?
In 0.25mg, 0.5mg, 1mg, 1.7mg and 2.4mg pens there are 4 doses, which means each pen will last for 4 weeks of treatment, as long as you’re taking 1 injection a week. When taking the 7.2mg dose, each dose comes in full as 7.2mg in a pre-filled, single-use dose which you must inject and discard. This means for 4 doses of 7.2mg you will receive 4 pens. We’ve created a guide about the different Wegovy dosages and when to take each one.
How to inject: Using the Wegovy pen
Before administering your Wegovy injection for the first time, read the Wegovy instructions in your patient information leaflet. Also, follow any advice that your doctor gives you. If you have trouble with your eyesight, you can ask someone to help you:
Here are a few tips on how to inject Wegovy safely:
For Wegovy 0.25mg, 0.5mg, 1mg, 1.7mg and 2.4mg pens:
- Make sure you’ve chosen the correct dose for where you are in the dosing schedule.
- Check the medication before administering it, especially if you take other injectable pens.
- As Wegovy is an injectable pen, you can take it with or without food.
- The best place to inject Wegovy is your upper legs or stomach (leaving a 5cm gap around your belly button).
- Inject Wegovy into a different place each week to minimise the risk of irritation, soreness, and redness at the injection site.
For Wegovy 7.2mg pen:
- Always check you have the correct dose strength.
- Check the expiry date on the back.
- Check the pen window, the dose should be clear and colourless.
- Your needle is hidden underneath your needle cover, you must take it off as soon as you are ready to inject.
For full guidance on injecting Wegovy 7.2mg, read the patient information leaflet available with your medication.
Step-by-step guides on: How to take Wegovy
Browse these step-by-step overview guides on how to take Wegovy:
- multi-dose pen
- single-dose pen
Taking Wegovy with the multi-dose pen
For each dosage excluding Wegovy 7.2mg, these instructions will help you to take Wegovy correctly and safely:
Step 1: Check that Wegovy is clear and doesn’t have a colour. You can see the Wegovy injection liquid through the pen window. If it’s not, use a new pen. You also need a new needle for each injection. Check the needle for signs of damage and dispose if unsealed or bent.
Step 2: Wash your hands and the injection site with an alcohol wipe or soap and water. Then, attach the needle with the cap on until you’re ready to check the flow or inject.
Step 3: If you’ve not used this Wegovy pen before, you need to check the flow. If you have used it before, you can go straight to step 4.
Remove the outer and the inner needle cap and keep the outer cap for later. Turn the dose selector to ‘flow check’ (2 dots and a line). Point the needle up and press the dose button until it hits 0. You should see a small drop of medication at the tip. The pen is now primed and ready to use. If this doesn’t work, try using a new needle or pen.
Step 4: Set your dose using the dose selector. Make sure it lines up with the dose pointer (the small arrow beside the window).
Step 5: If you skipped step 3, it’s now time to remove the inner cap on the needle and save the outer cap for later. Make sure you can see the dose counter then insert the needle into your chosen injection site. Hold down the button until it reaches 0, then count to 6 after this before removing. You’ll hear a click when the injection starts and another during.
Step 6: Remove the Wegovy pen from your skin. A small drop of medication on the needle's tip is normal. You can gently press the area with a cotton pad if you’ve bled. Get rid of the needle carefully by attaching the outer needle cap you saved earlier. Dispose of this in a sharps bin and store Wegovy in a safe place until your next dose is due.
Taking Wegovy 7.2mg with the single-dose pen
This short visual guide can help you take Wegovy 7.2mg with the single-dose pen. Please always read the patient information leaflet for full guidance on injecting your 7.2mg pen.
Where do you inject Wegovy?
You should inject Wegovy into your
- upper legs or
- stomach (with a distance of 5cm to your belly button).
You can also inject it in the back of your upper arms if you can get someone to help you do this.
Never inject Wegovy into a vein or muscle.
What is the best time of day to inject Wegovy?
“It’s not important what time you choose to take your Wegovy shot, as long as you always do it on the same day and at the same time for each weekly injection. This makes it more effective and builds up in your system better. Try and find a day and time that work for you in your day-to-day life.” – Dr Babak Ashrafi, Clinical Lead for Service Expansion for Asda Online Doctor.
How often does Wegovy have to be injected?
Wegovy is taken once per week. You should not inject more than this unless:
- you’ve missed a dose, and it’s been 5 days or less (more on this in the next section)
- you’re still taking 2.4mg 3 times in a row to make up the 7.2mg dose
If you’re missing Wegovy doses frequently, this could make it less effective.
What if I miss a dose of Wegovy?
If you miss a dose of Wegovy and:
- it’s been less than 5 days – take your dose then carry on as normal, sticking to your regular Wegovy routine
- it’s been 5 days or longer – skip the dose and then carry on as normal from your next dose
Never take 2 doses of Wegovy at once to make up for a missed one, as this could cause side effects.
What happens when you stop taking Wegovy?
When you stop taking Wegovy, the effects of the medication will slowly go away. You’ll start to feel hungrier again.
Stopping Wegovy injections too early (less than 16 weeks into the treatment) may mean you put on any lost weight, especially if you stop your diet and exercise plan. If side effects are bothering you or you’re not seeing the results you expected, speak to your doctor.
Does it hurt to inject Wegovy?
All injections can hurt a little bit, but the Wegovy pen has been designed to be as quick and pain-free as possible. Taking it correctly, such as regularly changing injection sites, will minimise any pain or irritation.
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Who should not take Wegovy?
You should not normally take Wegovy injections if you have a body mass index (BMI) below 30 kg/m². You might be able to take Wegovy if your BMI is between 27 kg/m² and 30 kg/m², but only if you’ve got a weight-related health condition or risk factor, such as high blood pressure.
You should not take Wegovy injections if you:
- are pregnant, want to get pregnant, or are breastfeeding
- have allergies to semaglutide or any other ingredient in the Wegovy pen
- don’t have a prescription for it
Wegovy injections might not be suitable for you if have:
- inflammation of the pancreas
- severe kidney problems
- diabetes or complications of diabetes
- low blood sugar (glucose) levels
Speak to your doctor about your medical history and current medications, as they’ll be able to let you know whether Wegovy is suitable for you.
Frequently asked questions
How do I know the injection is working?
You should notice your appetite decreases, you feel fuller for longer after eating, and you experience less food noise than before. This change can be gradual and become more noticeable as you reach higher doses.
Do I need to attach a new needle for every single injection?
Yes, you need to use a new needle for each injection, even if you are using the same 2.4mg pen 3 times for the 7.2mg dose. If you are using the single-dose 7.2mg Wegovy pen, you do not need to attach a needle, it is already included in the pen.
Does Wegovy come with needles?
Yes, you’ll get needles with each Wegovy pen to administer your doses.
Can you inject Wegovy cold?
Yes, Wegovy can be injected cold. Before opening your Wegovy pen, store it in a fridge between 2°C and 8°C. Once opened, keep it in the fridge or a safe place away from direct sunlight, below 30°C.
Never freeze Wegovy, try to heat it up, or take a dose if the pen has been frozen.
Should I inject semaglutide in the morning or at night?
It doesn’t matter if you take semaglutide in the morning or at night. Just stick to the same time and day every week and find a routine that works for you.
Dr Kathryn Basford is a qualified GP who works as a GP in London, as well as with ZAVA. She graduated from the University of Manchester and completed her GP training through Whipps Cross Hospital in London.
Meet our doctorsLast reviewed: 02 Jun 2026
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The New England Journal of Medicine (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity: https://www.nejm.org/doi/full/10.1056/NEJMoa2032183, [accessed 26 January 2026]
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JAMA Network (2015). Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: https://jamanetwork.com/journals/jama/fullarticle/2428956, [accessed 26 January 2026]
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Obesity (2023). NHS: https://www.nhs.uk/conditions/obesity/treatment/, [accessed 26 January 2026]
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EMC (2022). Wegovy 1 mg, FlexTouch solution for injection in pre-filled pen: https://www.medicines.org.uk/emc/product/13801/smpc, [accessed 26 January 2026]
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The New England Journal of Medicine (2022). Tirzepatide Once Weekly for the Treatment of Obesity: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038, [accessed 26 January 2026]
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