Estriol 1mg cream is a cream that is inserted into the vagina and contains the active ingredient, estriol. This is used to treat vaginal dryness in women who are postmenopausal. Estriol cream is known as a hormone replacement therapy (HRT) as it replaces the oestrogen lost naturally during menopause. The usual dose is 1 applicator a day for 2 to 4 weeks, followed by 1 applicator, 2 times a week.
160 days / 1 x 80 g tube(s) - £50.00
About Estriol Cream
How to use Estriol cream
Estriol cream comes with an applicator, which is inserted into the vagina, usually at bedtime. The usual dose is 1 applicator of 0.5 mg of cream, which contains 0.5 mg of estriol. This is measured by the red ring around the applicator. Estriol cream is used once a day for 2 weeks when first prescribed. After the first 2 weeks, it should be used 2 times a week.
Follow these steps to use your estriol cream:
- Remove the cap from the estriol cream and turn it upside down. Use the sharp end to open the tube.
- Attach the applicator to the tube by screwing it on.
- Squeeze the tube and fill the applicator with cream, up to the red line. The plunger will stop at the red line.
- Unscrew the cream from the applicator and replace the cap.
- It is best to apply the cream at bedtime, once you are ready to go to sleep. Lie down and put the applicator deep into your vagina, with the plunger on the outside.
- Slowly push the plunger to release the cream into your vagina.
After you have used the applicator, remove the plunger from the applicator and wash both in hot, soapy water. Never use boiling water or detergents and rinse well with water after cleaning. If you forget your dose, apply the cream when you remember, unless it has been over 12 hours since it was due. If it is more than 12 hours, skip that dose and wait until your next dose. Do not use more cream to make up for your missed dose as this could cause vaginal bleeding.
Estriol cream is a medication that contains 1 milligram of the active ingredient estriol. It belongs to a group of medicines called hormone replacement therapy (HRT). Estriol cream is used for women who have menopausal symptoms which affect the vagina. The cream is inserted into the vagina with an applicator and can relieve symptoms such as irritation and dryness (vaginal atrophy). Estriol cream is the unbranded version of this medication. You can also find this medication under the branded name of Ovestin 1mg cream.
When you go through menopause, your oestrogen levels begin to drop. A loss of oestrogen can cause the vaginal wall to get dry. This can cause other symptoms such as pain during sex and vaginal infections. Estriol can replace the levels of oestrogen in your body and relieve these symptoms.
As estriol cream is inserted directly into the vagina, the hormone is released where it is needed. It may take just a few weeks before you to see an improvement. Unlike some oestrogen treatments, estriol cream does not need to be taken with progesterone.
Estriol cream is not suitable for you if you have:
- an allergy to estriol or any ingredients in the cream
- breast cancer, or have ever had it
- cancer sensitive to oestrogen, such as cancer of the womb lining
- a blood clot or blood clotting disorder
- vaginal bleeding that cannot be explained
- had a heart attack, angina, or a stroke
- liver disease, or have ever had it
- thickening of the womb lining
- a rare blood problem known as porphyria
Some generic estriol cream contains arachis oil (peanut oil), so if you have a peanut allergy you should check the product information leaflet or box to be sure before using this.
If you are not sure, you can message our doctors before using estriol cream.
If you have other menopause symptoms, as well as vaginal dryness, there are other types of HRT medications that can be used.
- tablets that contain oestrogen or progesterone, or both, like Elleste duet conti tablets
- vaginal rings, like ESTRING
- other vaginal creams, or gels, such as Ovestin
- patches, like Estradot 50
There are other ways to stop vaginal itching or dryness, such as vaginal lubricants or moisturisers. These can be found over the counter and can be used instead of estriol cream, or alongside it. If you have vaginal dryness, using unperfumed products around the vagina may also help with symptoms.
You should let your doctor know about any medications that you are using before starting estriol cream, in particular if you are using:
- medication for epilepsy
- herbal medication containing St John’s wort
- medication to treat HIV or Hepatitis C
Estriol cream can have some side effects but not everybody will get them. You may get some itching or irritation around the vagina when you first use the cream, but this should get better after a few weeks of treatment.
Some other side effects include:
- an increase in vaginal discharge, bleeding, or spotting
- flu symptoms
- gallbladder problems
- nausea or vomiting (feeling or being sick)
- swollen, tender, or painful breasts
- rash on the skin
- an allergy to the sun
If you get any of these side effects, speak to your doctor, as you may need to stop using the cream.
Estriol cream may have some serious side effects, such as:
- an increase in blood pressure
- jaundice symptoms, such as yellowing of the skin or white of the eyes
- signs of a blood clot, such as pain in the legs or dizziness
If you get any of these side effects, speak to your doctor straight away. For further information on side effects of estriol cream, read the patient information leaflet.
Speak to your doctor before using estriol cream if you have:
- high blood pressure
- fibroids in your womb
- problems with your womb lining
- a risk of blood clots
- family history of cancer that is sensitive to oestrogen
- a liver disorder
- severe headaches or migraines
- an immune system disease
- a disease affecting hearing called otosclerosis
- fluid retention because of kidney or heart problems
If you have any of these, you may still be able to use estriol cream but only if your doctor has said it's okay. You should have regular visits with your doctor, to make sure estriol cream is still suitable for you.
Can estriol cream cause weight gain?
There are some beliefs that taking HRT, including estriol cream, can cause weight gain. During menopause, some women may gain weight, but this is due to menopause, rather than HRT medication. When using a vaginal cream such as estriol cream, there is no link to weight gain.
Dr Kathryn Basford
Dr Kathryn Basford is a qualified GP who works as a GP in London, as well as with ZAVA. She graduated from the University of Manchester and completed her GP training through Whipps Cross Hospital in London.Meet our doctors
Article created: 05 Oct 2021
Last reviewed: 05 Oct 2021
Hormone replacement therapy (HRT) (2019) NHS (accessed 09 September 2021)
Menopause (2018) NHS (accessed 07 September 2021)
Menopause and Natural Ways to Cope (2018) Hull University Teaching Hospitals NHS Trust (accessed 07 September 2021)
Ovestin 1 mg cream (2020) EMC (accessed 09 September 2021)
Vaginal dryness (2018) NHS (accessed 09 September 2021)